FORMULATION AND OPTIMIZATION OF PERINDOPRIL ERBUMINE FAST-DISSOLVING ORODISPERSIBLE TABLETS

Dr. Amol U. Gayke*, Prasad A. Mokal, Prof. Vikas Shinde, Riddhi D. Thorat, Dr. Sushil Patil

The present study aimed to formulate and evaluate orodispersible tablets (ODTs) of Perindopril Erbumine using natural, synthetic, and co-processed superdisintegrants to enhance disintegration, dissolution, stability and bioavailability. Perindopril Erbumine, an ACE inhibitor with limited oral bioavailability (40–45%) and a half-life of 5–10 hours, is used in the treatment of hypertension and cardiovascular conditions. ODTs were prepared via direct compression using Irbesartan as active ingredient, HPMC, Eudragit L 100, Aspartame, Ethyl cellulose, Dimethyl sulfoxide, Propylene glycol, Ethanol and superdisintegrants such as Moringa oleifera, Crospovidone, and Croscarmellose, including co-processed blends (1:1 ratios) at concentrations of 10% and 15%. FTIR studies confirmed no drug–excipient interactions. Pre-compression and post-compression evaluations indicated good flow properties and acceptable physical characteristics. Among all formulations, F7 (Moringa oleifera and Crospovidone, 1:1 at 10%) demonstrated optimal performance with the shortest disintegration time (21 sec), wetting time (27 sec), and highest drug release (99.5% at 30 minutes). This study highlights the potential of natural-synthetic co-processed superdisintegrants in developing effective orodispersible formulations.