World Journal of Pharmaceutical
Science and Research

A Global Platform for Open Access, Peer-Reviewed, and Indexed Research in the
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ISSN: 2583-6579


Impact Factor: 5.111

ABSTRACT

THE ROLE OF EXCIPIENTS IN DRUG BIOAVAILABILITY AND PHARMACOLOGICAL RESPONSE

Sonali Behera*, Sulochana Dutta, Ranjit Paikray, Seshadev Jena, Amulya Kumar Das, Sayed Tashkilur Rashedin

Excipients, once considered inert formulation components, are now recognized as critical determinants of drug bioavailability and pharmacological response. Their role extends beyond structural and stabilizing functions, directly influencing the absorption, distribution, metabolism, and excretion (ADME) of active pharmaceutical ingredients (APIs). This paper explores the multifaceted contributions of excipients in drug delivery, emphasizing their impact on solubility, stability, taste masking, and patient compliance. Functional excipients such as surfactants, polymers, cyclodextrins, and preservatives are discussed with regard to their ability to enhance drug dissolution, maintain stability under environmental stress, and ensure microbial safety. Particular attention is given to the interactions between excipients and APIs, highlighting how these interactions alter pharmacokinetic and pharmacodynamic profiles, potentially enhancing or compromising therapeutic outcomes. Recent evidence also demonstrates the influence of excipients on enzymatic pathways and the gut microbiota, underscoring their clinical significance. With advances in formulation science, excipients are evolving into biofunctional agents that can improve therapeutic predictability, minimize adverse effects, and enhance patient safety. Understanding these roles is essential for rational excipient selection in modern pharmaceutical development, ensuring reproducible drug efficacy across diverse patient populations.

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