INTEGRATION OF NANOTECHNOLOGY IN HERBAL MEDICINE: EMERGING TRENDS, CHALLENGES, AND FUTURE PROSPECTS

Nitin Mahale, Ajay Bhagwat, Santosh Ghule, Shubham Kanade*, Shubham Bhujbal, Swapnil Auti

Herbal medicines have been an important source of therapeutic agents for a long time because they come from natural sources and generally have fewer side effects. Many herbal bioactives face issues such as low solubility, reduced bioavailability, instability, and limited specificity to their targets. Combining nanotechnology with herbal medicine has created new opportunities to address these issues. Different types of nanocarrier systems, including polymeric nanoparticles, solid lipid nanoparticles, liposomes, nanoemulsions, and metallic and magnetic nanoparticles, have been created to improve the solubility, stability, targeted delivery, and controlled release of plant-derived compounds. These nanostructured systems enhance the pharmacokinetics of herbal medications, lower the necessary dosage, and decrease toxicity while preserving or improving their therapeutic effectiveness. Examples include nanoformulations of curcumin, quercetin, berberine, and silymarin that demonstrate enhanced effects in cancer prevention, antioxidant activity, inflammation reduction, and liver protection. Techniques like scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), and dynamic light scattering (DLS) are used to assess particle size, shape, and surface charge. While nanotechnology presents notable benefits, there are still concerns about its scalability, safety, and regulatory issues. Nanotechnology-based delivery systems offer a promising method to convert traditional herbal medicines into scientifically validated, effective, and targeted modern treatments.