1,5 BENZODIAZEPINE AS A ANTIEPILEPTIC ACTIVITY

Rajashri Sanjay Shinde*, Devayani Ravindra Agrawal, Shivani Murlidhar Khandagale

Epilepsy is characterized by the presence of recurrent seizures. A seizure can be defined as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex”. One in every three patients with epilepsy is probable to be severely disabled. It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. Recently discovery of benzothiazepine derivatives as an anticonvulsant agent is significant area for research in medicinal chemistry as it is free from all side effects which is shown by a developed as an anticonvulsant agent. In these we have presented result of 2D and 3D docking poses of molecule containing 1,5 benzodiazepine pharmacophore as anticonvulsant agents Docking analysis was utilized to predict the mechanisms of action of the designed derivatives for anticonvulsant potential. All the molecule exhibited binding score in the range of 7.5 to 8.5. It was noted that the docking score of 2BXF was almost same as that of selected standard range i.e 7.5 as potent anti-epileptic agent.