A COMPREHENSIVE REVIEW: HOLARRHENA PUBESCENS

Dr. M. J. Patil, Vibhuti S. Shirsat, Akshay M. Nar, Maithili Mahendra Panchal*

Kurchi, or Holarrhena pubescens, is a herb that contains bioactive substances such glycosides, alkaloids, tannins, and flavonoids.Medicinal plants are used to treat a wide range of illnesses and are essential to human health care. The Apocynaceae family includes the genus Holarrhena, which is primarily found in tropical Africa, southern continental Asia, and Sri Lanka. Historically, many Holarrhena species have been used to treat a variety of illnesses, including hallucinations, fatigue, skin issues, leprosy, biliousness, and diarrhea. Crucially, the bark and its preparations have long been utilized for their medicinal qualities in traditional medicine across the globe. Its antidiarrheal, antimalarial, hepatoprotective, antioxidant, anti-inflammatory, anticancer, anti-wound-healing, and anti-diabetic properties have all been shown in studies. Additionally, it decreases intestinal motility and reducing the frequency and intensity of diarrhea by promoting the passage of fluids and electrolytes. Strong anti-plasmodial efficacy against Plasmodium falciparum is demonstrated by its bark extract. It lowers oxidative stress and strengthens antioxidant defense.