FORMULATION AND EVALUATION OF ORAL DISPERSIBLE TABLET OF POORLY WATER-SOLUBLE DRUG ‘GLIMEPIRIDE’ USING SOLUBILTY ENHANCEMENT TECHNIQUE

Arpit Gawshinde*, Yamini Nagar, Ali Dabeer, Anamika Daniel, Dr. Dharmendra Solanki, Pushpanjali Chaurasia

According to BCS Glimepiride undergoes Class II - High Permeability and Low Solubility drug The objective of the research project is to enhance the solubility of Glimepiride by using solubility enhancement techniques. In the pharmaceutical business, oral drug delivery is the gold standard since it is thought to be the safest, most practical, and most affordable route of drug delivery with the highest patient compliance. In contrast to other traditional oral solid dosage forms, oral dispersible tablets (ODTs) are a unique oral solid dosage form that quickly dissolves in the mouth without chewing or drinking any water. It is estimated that less than a minute is the ideal amount of time for an Oro dispersible tablet to become separate. The degeneration times are often generated via direct compression, solid dispersion. Oral dispersible tablet of Glimepiride was prepared by direct compression method. ODTs of glimepiride by using different super disintegrate such as sodium starch glycolate, cross povidone and croscarmellose sodium. Further, post evaluation parameters like Shape and Color of Tablets, Thickness, hardness, friability, weight variation, Uniformity of Drug Content, In vitro Dissolution Rate Studies and In-vitro disintegration time were also evaluated and the results were discussed.