REVIEW ON NANOSPONGES: A NOVEL DRUG DELIVERY SYSTEM

Varsha Ghotkule*, Kadambari Ghatpande, Diya Gawade, Manish Madli

By providing innovative methods for enhancing the effectiveness, safety, and patient compliance of therapeutic drugs, nanotechnology has completely transformed the field of pharmaceutical sciences. Nanosponges are one of the new nanocarriers that have garnered a lot of interest as a novel drug delivery method that can improve the solubility, stability, and controlled release of both hydrophilic and lipophilic medications. By encasing active medicinal ingredients within their three-dimensional network, nanosponges—porous, nanosized polymeric structures—can prevent degradation and enable controlled, prolonged drug release. Polymers like β-cyclodextrin, ethyl cellulose, or polyvinyl alcohol can be used to create these systems utilizing techniques including solvent evaporation, ultrasound-assisted synthesis, or emulsion solvent diffusion. Nanosponges have demonstrated promise uses in topical, oral, and parenteral formulations for the administration of antifungal, anti-inflammatory, and anticancer drugs. They could serve as a platform for upcoming drug delivery advances due to their high loading capacity, biocompatibility, and capacity to increase bioavailability. The design, manufacture, characterisation, and therapeutic usage of nanosponges as an innovative and adaptable drug delivery method are the main topics of this review.