STRUCTURE - ACTIVITY RELATIONSHIP (SAR) TRENDS OF AZO BASED MEDICINES: MEDICINAL CHEMISTRY PERSPECTIVES AND EMERGING APPLICATIONS

Dr. S. Sandy Subala*, Dr. Sumathi K. Sripathi

Azo based compound, characterized by the presence of the -N=N- azo linkage, represent a unique and versatile class of molecules in medicinal chemistry. Although historically associated with dyes and pigments, azo derivatives have demonstrated significant pharmacological potential, including antimicrobial, anti inflammatory, antioxidant, anticancer, and targeted prodrug applications. The biological performance of azo compound is strongly governed by their structural features, including electronic substituent effects, aromaticity, heterocyclic integration, steric modulation, and metabolic reducibility. This review comprehensively examines structure-activity relationship (SAR) trends governing azo based medicinal agents. Emphasis is based on electronic and steric influences, heteroaromatic scaffolds, redox behavior, enzyme-mediated bioreduction, metal coordination, and emerging photopharmacological strategies. Toxicological considerations and computational SAR correlations are also discussed. BY consolidating recent advances, this review provides rational design principles for developing safer and more effective azo-based therapeutics.