CANDESARTAN, A POORLY SOLUBLE DRUG, WAS FORMULATED AND EVALUATED AS NANOSUSPENSION

J. Praveen Kumar*, Sathish M., Dr. D. Jothieswari

Formulating medications with low solubility presents significant hurdles for the pharmaceutical business, as it reduces the drugs' therapeutic efficacy and bioavailability. A workable remedy is offered by nanosuspensions, a consequence of nanotechnology that dramatically improves drug dissolving and saturation solubility by reducing particle size to the submicron range. By creating, synthesizing, and carefully characterizing nanosuspensions, this extensive study seeks to improve the effectiveness and delivery of medication in a variety of medicinal applications, especially for poorly soluble drugs. A Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM). These studies contribute to the further improvement and optimization of the formulations by providing a thorough understanding of the thermal and structural characteristics of the thorough Preformulation study covering essential components, such as drug- excipient compatibility tests, is the first stage of the research process. Comprehending these essential connections is vital for effective formulation. The next step involves creating nanosuspensions by an ultrasonication-antisolvent precipitation method. The careful selection of stabilizers and solvents is necessary to ensure stability and efficacy while optimizing the formulation process. Deep insights into the physicochemical properties of the nanosuspension can be gained by physicochemical and analytical characterization using cutting-edge methods like Differential Scanning Calorimetry (DSC), Fourier Transform Infrared drug particles at the nanoscale. A detailed analysis of important factors, such as drug and stabiliser concentrations, the volume ratio of solvent to antisolvent, the speed of stirring, and the length of sonication, is necessary to optimize the properties of nanosuspension. In vitro drug release experiments employ the resultant nanosuspensions, enabling a comprehensive comparison with unmilled suspensions and commercially available formulations. This paper also examines the fabrication technique of lyophilized nanosuspensions, which improves the formulations’ stability and convenience of use over storage and provides a useful solid unit dosage form for medications with low water solubility. This talk focuses on the structural configurations and diverse applications of polaxemer (188and457), sodium lauryl sulfate, povidone (PVP K-30), and polyvinyl alcohol.