DESIGN, DEVELOPMENT AND EVALUATION OF GLIMEPIRIDE FLOATING BEAD TO IMPROVE THE SUSTAIN RELEASE OF DRUG

Radheshyam Samanta*, Pravati Deo, Ashok Kumar Sethi, Rajesh Kumar Swain, Nihar Ranjan Barik, Rajeswari Pradhan, Motirekha Pradhan, Madhuchhanda Jena, Sukanta Nayak, Arup Kumar Pan

The current work attempted to developed glimepiride floating beads made of sodium alginate and xanthan gum by ionotropic emulsifying gelation method was to evaluate their morphology, % of yield value, drug entrapment efficiency, drug content uniformity, in vitro floatation. In addition, in vitro drug release was performed. The different evaluated properties like morphological charecteristic, % of yield value, drug entrapment efficiency, drug content uniformity, in vitro floatation etc prove that rough surface to improve the drug release, good drug present due to better entrapment, excellent floatation to stability and developed the beads. Also the in vitro release of drug in all formulation (especially GB5) is more 12 hours in phosphate buffer (pH7.4). So, it was clearly stated that the formulation of glimepiride beads prepared by addition of suitable polymeric mixture, namely sodium alginate and xanthan gum with olive oil and Tween 80 by emulsifying ionotropic gelation method help to retain and sustain release the drug for prolong periods of time in the intestine.