GREEN NANOTECHNOLOGY APPROACH FOR THE DEVELOPMENT OF HERBAL-BASED NANOPARTICLES IN WOUND HEALING

Smrutiranjan Dash, Kushagra Jha*, B. Meenal

Wound healing is a complex biological procedure that happens in numerous stages, together with tissue remodelling, proliferation, inflammation and haemostasis. Conventional technique of curing wounds frequently have difficulty such as antibiotic resistance, cytotoxicity, and not enough tissue regeneration. Green nanotechnology, which uses plant-based reducing and capping agents to make nanoparticles, has become a sustainable and biocompatible option. This review methodically analyses the green synthesis of herbal-derived nanoparticles, including silver, gold, zinc oxide, copper oxide, and titanium dioxide nanoparticles, sourced from medicinal plants such as aloe vera, curcuma longa, centella asiatica, azadirachta indica, and camellia sinensis. The wound healing mechanisms of these nanoparticles are examined, including antimicrobial activity, anti-inflammatory properties, antioxidant effects, promotion of collagen synthesis, stimulation of angiogenesis, and re-epithelialization. The research highlights the integration of herbal nanoparticles into advanced delivery systems called as hydrogels, nanofiber scaffolds, and transdermal patches. The matter associated with standardization, scalability, toxicological assessment, and regulatory clearance have been taken into consideration in this work. The aim of the literature review is to emphasize the potentiality of using plant-mediated synthesis of nanoparticles as an eco friendly approach for the development of the next generation of wound healing treatments.