FORMULATION AND EVALUATION MUCOADHESIVE BUCCAL PATCHES OF TRIAMCINOLONE ACETONIDE AND LIDOCAINE HYDROCHLORIDE FOR EFFECTIVE TREATMENT OF MOUTH ULCERS

Rohan Badetiya*, Dr. Sanjay Dhaker, Sahdev Sharma, Dinesh Upadhyay, Subhranshu Panda

Oral ulcers are common and painful lesions of the oral mucosa that significantly affect eating, speaking, and overall quality of life. Conventional topical treatments such as gels and ointments often suffer from poor retention at the site of application due to salivary washout and mechanical disturbances, leading to reduced therapeutic efficacy. The present study aimed to develop and evaluate mucoadhesive buccal patches containing Triamcinolone Acetonide and Lidocaine Hydrochloride for effective management of oral ulcers. The buccal patches were prepared using the solvent casting method with suitable polymers such as HPMC and Carbopol to achieve sustained drug release and improved mucoadhesion. The prepared patches were evaluated for physicochemical parameters including thickness, weight variation, surface pH, drug content uniformity, swelling index, mucoadhesive strength, and in vitro drug release. The results demonstrated that the formulated patches were smooth, flexible, and exhibited uniform drug distribution with a surface pH compatible with oral mucosa. The patches showed good swelling behavior, adequate mucoadhesive strength, and a controlled drug release profile. Lidocaine hydrochloride provided immediate analgesic action, while triamcinolone acetonide ensured sustained anti-inflammatory activity, promoting faster healing of ulcers. In conclusion, the developed mucoadhesive buccal patches represent a promising and effective drug delivery system for the localized treatment of oral ulcers, offering prolonged residence time, improved patient compliance, and enhanced therapeutic outcomes.