MOLECULAR DOCKING OF HERBAL COMPOUND (CURCUMIN)

Sainath Vijaysing Gadekar*, Dr. Rahul Prakash Lokhande, Parth Dnyaneshwar Dathkhil, Shrutika Pralhad Gadge, Aditya Sampat Dere, Sakshi Rajesh Gaikwad, Tanvi Sopan Dongare

Curcumin is an important thing in pharmaceutical sciences. This is because it can affect different things that happen inside our cells. There is a big problem when it comes to using curcumin in medicine. It does not get absorbed by our bodies well. This review looks at some studies that used computers to see how curcumin interacts with certain targets in our body like NF-κB, CDK2 and the PI3K/Akt pathway. We want to understand how curcumin works and how it can affect different things at the same time. We also want to look at the bad things about using computers to design new drugs. The big problem with curcumin is that it does not get absorbed by our bodies well. We can use computers to help us find ways to make it work better. For example, we can use computers to find the combinations of ingredients to mix with curcumin. This paper state that what various studies not defines. It suggests some new ways that we can use curcumin to make new drugs. In the future we can use computers to make better predictions, about how curcumin will work. We can use something called dynamics and artificial intelligence to make our predictions more accurate. This will help us make drugs that use curcumin and that will really work well. We can make tiny formulations of curcumin that will get absorbed by our bodies and will be very effective.