FORMULATION AND EVALUATION OF MICROEMULSION BASED HYDROGEL FOR TOPICAL DRUG DELIVERY SYSTEM OF KETOCONAZOLE

Nakul Kathar, Abhay Kamble*, Abhijeet Jadhav, Vishal Davhad, Dipali Tidke, Akshata Raut and Dr. Gajanan Sanap

The goal of the current study was to create a hydrogel formulation based on microemulsions for the topical application of ketoconazole that has increased microbiological activity while avoiding systemic side effects. A medication with antifungal properties. Oleic acid was chosen after several oils were evaluated for drug solubility. To create microemulsions, various cosurfactants and surfactants were evaluated. Specifically, Propylene Glycol and Twee 80. The hydrogel based on microemulsion was created using Carbopol 934 as a gel matrix to increase the viscosity of the microemulsion for topical application. Zeta Potential, pH, visual inspection, thermodynamic stability (heating and cooling cycle), and infrared spectroscopy were all used to assess the improved microemulsion. Following the test, the microemulsion we had chosen proved to be completely stable.