FORMULATION AND EVALUATION OF ANTIFUNGAL SPRAY

Prof. Kshitij S. Varma*, Vedant V. Sonawane, Siddhi S. Sonawane, Sapna K. Sonawane, Rushikesh S. Sonawane, Bhushan M. Shirsath and Shubham S. Shirsath

Fungal infections, particularly those affecting large or difficult-to-reach areas, present significant challenges in treatment due to limited drug penetration, short duration of action, and issues with patient adherence. Traditional antifungal therapies, including creams and oral medications, often fail to meet these needs effectively. This study investigates the development of a novel antifungal spray designed to overcome these limitations by ensuring controlled drug release and enhanced therapeutic efficacy. The formulation utilizes a bio adhesive and film-forming base, promoting uniform application and prolonged retention of the active ingredient. Extensive evaluation, including physicochemical characterization, in vitro drug release studies, spray pattern analysis, and antifungal efficacy testing against common pathogens, demonstrated that the spray formulation offers improved stability, sustained drug release, and potent antifungal activity. These findings suggest that the spray is a promising alternative for managing fungal infections, providing both effectiveness and convenience for patients.